Blar i forfatter "Henriksen, Stian"

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    • Does the Evidence Support the Existence of the Simian Polyomavirus SV40 Vp4 Viroporin? 

      Henriksen, Stian; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-18)
      The simian polyomavirus SV40 was reported to express Vp4, an N-terminally truncated form of the minor capsid proteins Vp2 and Vp3. Since a missense mutation of the putative Vp4 start codon (Vp2M228I) was found to give reduced progeny release and delayed lysis, Vp4 was claimed to be a viroporin. However, two independent research groups, including our own, were unable to replicate these findings. ...

    • Early fulminant BK polyomavirus-associated nephropathy in two kidney transplant patients with low neutralizing antibody titers receiving allografts from the same donor 

      Lorentzen, Elias Myrvoll; Henriksen, Stian; Kaur, Amandeep; Kro, Grete Birkeland; Hammarström, Clara; Hirsch, Hans H; Midtvedt, Karsten; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed; Mastergradsoppgave; Master thesis, 2020-01-10)
      <i>Background</i> - BK Polyomavirus (BKPyV) causes premature graft failure in 1 to 15% of kidney transplant (KT) recipients. High-level BKPyV-viruria and BKPyV-DNAemia precede polyomavirus-associated nephropathy (PyVAN), and guide clinical management decisions. In most cases, BKPyV appears to come from the donor kidney, but data from biopsy-proven PyVAN cases are lacking. Here, we report the early ...

    • Modelling BK Polyomavirus dissemination and cytopathology using polarized human renal tubule epithelial cells 

      Lorentzen, Elias Myrvoll; Henriksen, Stian; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-28)
      Most humans have a lifelong imperceptible BK Polyomavirus (BKPyV) infection in epithelial cells lining the reno-urinary tract. In kidney transplant recipients, unrestricted high-level replication of donor-derived BKPyV in the allograft underlies polyomavirus-associated nephropathy, a condition with massive epithelial cell loss and inflammation causing premature allograft failure. There is limited ...

    • The Presumed Polyomavirus Viroporin VP4 of Simian Virus 40 or Human BK Polyomavirus Is Not Required for Viral Progeny Release 

      Henriksen, Stian; Hansen, Terkel; Bruun, Jack-Ansgar; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-14)
      The minor capsid protein of human BK polyomavirus (BKPyV), VP2, and its N-terminally truncated form, VP3, are both important for viral entry. The closely related simian virus 40 (SV40) reportedly produces an additional truncated form of VP2/3, denoted VP4, apparently functioning as a viroporin promoting progeny release. The VP4 open reading frame is conserved in some polyomaviruses, including BKPyV. ...

    • Risk factors, immune response and whole‐genome sequencing of SARS‐CoV‐2 in a cruise ship outbreak in Norway 

      Gravningen, Kirsten Midttun; Henriksen, Stian; Hungnes, Olav; Svendsen, Kristian; Macdonald, Emily Ann; Schirmer, Henrik; Stene-Johansen, Kathrine; Simonsen, Gunnar Skov; Kacelnik, Oliver; Elstrøm, Petter; Bragstad, Karoline; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-18)
      Objective: To improve understanding of SARS-CoV-2-transmission and prevention measures on cruise ships, we investigated a Norwegian cruise ship outbreak from July to August 2020 using a multidisciplinary approach after a rapid outbreak response launched by local and national health authorities. Methods: We conducted a cross-sectional study among crew members using epidemiologic data and results ...

    • Seroprevalence of hepatitis E virus (HEV) in a general adult population in Northern Norway: the Tromsø study 

      Olsøy, Irene Beate; Henriksen, Stian; Weissbach, Fabian H.; Larsen, Marthe; Borgen, Karoline; Abravanel, Florence; Kamar, Nassim; Paulssen, Eyvind Jakob; Hirsch, Hans H.; Rinaldo, Christine Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-22)
      Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in many parts of the world but only a few cases have been diagnosed in Norway. To investigate the HEV exposure rate in a presumed low-risk area, we have conducted a population-based study of anti-HEV IgG seroprevalence in Northern Norway. A total of 1800 serum samples from 900 women and 900 men, age 40–79 years, were randomly selected ...

    • Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. Viruses 2022, 14, 2070 

      Rinaldo, Christine Hanssen; Henriksen, Stian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-29)
      A recent paper in Viruses investigates the impact of the JC polyomavirus (JCPyV) microRNA on the replication of different JCPyV strains. Unfortunately, one of the cell lines used, the human fetal glial cell line SVGp12, is productively infected by the closely related BK polyomavirus (BKPyV), which may confound results. Scientists need to take this into account and the potential pitfalls.